Brain Peptides
نویسندگان
چکیده
منابع مشابه
Brain and gut peptides.
The first evidence that the same peptides could be present in both the brain and the gut was given in 1931 with the discovery of substance P (Von Euler and Gaddum, 1931). In spite of this early start, the important revelation that there were a large number of peptides with this dual localisation and also with powerful and extensive pharmacological actions took more than 40 years to materialise....
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The brain is both the source and the recipient of peptide signals. The question is: Do endogenous, blood-borne peptide molecules influence brain function? Brain regions with the tight capillaries of the blood-brain barrier (BBB) extract low but measurable amounts of labeled peptide molecules from an intracarotid bolus injection. In the rat, the extraction fractions of beta-casomorphin-5, DesGly...
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Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract but is also found in high density in the mammalian brain. The C‐terminal sulfated octapeptide fragment of CCK8 constitutes one of the major neuropeptides in the brain. CCK8, interacting with nanomolar affinities with two different receptors designated CCK1 and CCK2, has been shown to be involved in numerous p...
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The authors present an overview of the main amphibian peptide families mainly derived from the skin and mostly discovered by Erspamer and his associates. The studies of the peptides do not only promote the understanding of their chemical, metabolical and physiological features of those molecules in amphibians, but also contribute to progress in our knowledge of the corresponding mammalian count...
متن کاملBrain and other natriuretic peptides: molecular aspects.
Natriuretic peptides have emerged as important candidates for development of diagnostic tools and therapeutic agents in cardiovascular disease. The family contains of three major peptides-ANP, BNP, CNP-that participate in cardiovascular and cardiorenal homeostasis. Each of these natriuretic peptides binds differentially to specific receptors that signal through different mechanisms. They are cl...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1984
ISSN: 0022-3050
DOI: 10.1136/jnnp.47.11.1261